Volume 4, Issue 1, June 2019, Page: 5-10
Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives
Ekwere Ifeoma Toyin, College of Health Sciences, Delta State University, Abraka, Nigeria
Naiho Alexander Obidike, College of Health Sciences, Delta State University, Abraka, Nigeria
Ojieh Emeka Anthony, College of Health Sciences, Delta State University, Abraka, Nigeria
Odigie Mike Osagie, College of Health Sciences, Delta State University, Abraka, Nigeria
Ohwin Peggy Ejiro, College of Health Sciences, Delta State University, Abraka, Nigeria
Received: May 20, 2019;       Accepted: Jun. 24, 2019;       Published: Jul. 13, 2019
DOI: 10.11648/j.aap.20190401.12      View  56      Downloads  19
Abstract
Overtime, Diastolic dysfunction (DD), which is seen in damping blood, and pressure build up within the ventricles has been associated with different disease states including chronic hypertension, coronary heart disease, aging, aortic stenosis, hypertrophic and restrictive cardiomyopathies. Diagnosis is by echocardiography (ECG) and often cumbersome. Howbeit, in acute stages of hypertension, prolongation of ventricular activation time in an ECG session has been described as potential marker for diagnosing DD. Current study was therefore undertaken to investigate ventricular activation time in essentially hypertensive Nigerians. One hundred and sixty two (162) hypertensives were recruited for the study. Their compliance to antihypertensive medication, blood pressure control, and electrocardiographic changes were determined and measured. Venous blood sample was then drawn and placed in special tubes to determine the serum magnesium concentrations, using a standard Colorimetric assay machine, Using the statistical measure of association (correlation), correlation between serum magnesium and ECG parameters was calculated using the Pearson’s correlation coefficient. One way analysis of variance (ANOVA) was also explored in obtaining differences in mean between variables. From our observations, only a weak correlation was found between serum magnesium levels and ECG findings across the study population. This proved statistically insignificant at p < 0.05. Other factors such as antihypertensive medications, duration of blood pressure and the control of blood pressure did not show any significant relationship.
Keywords
Diastolic Dysfunction, Magnesium, Hypertension
To cite this article
Ekwere Ifeoma Toyin, Naiho Alexander Obidike, Ojieh Emeka Anthony, Odigie Mike Osagie, Ohwin Peggy Ejiro, Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives, Advances in Applied Physiology. Vol. 4, No. 1, 2019, pp. 5-10. doi: 10.11648/j.aap.20190401.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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