Volume 3, Issue 1, June 2018, Page: 1-7
The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats
Milad Rezazadeh, Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran
Mehdi Ahmadifar, Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran; Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Meysam Ahmadi Manesh, Department of Animal Sciences, Faculty of Agriculture and Natural Resources, Gonbad Kavous University, Gonbad-e Kavus, Iran
Received: Jan. 25, 2018;       Accepted: Feb. 16, 2018;       Published: May 29, 2018
DOI: 10.11648/j.aap.20180301.11      View  1554      Downloads  167
Methamphetamine is sometimes prescribed by doctors for specific diseases that with the entering the central nervous system caused by a sudden release of categulamine and particularly dopamine in the brain. It stimulates brain cells, enhancing aggressive mood and increased body movement. The purpose of this study was to investigate, has been the effects of methamphetamine on passive avoidance learning and memory in adult male Wistar rats. Male Wistar rats of rats in the weight range (180-220gr) (N=6) was Divided into healthy group - control group (saline received) and dose received groups (1.5, 3, 5 mg/kg). Half an hour before the test, intraperitoneally injection was done and after the test, every day at specific times for long-term memory test for one week Injection was done. Results have shown that the incidence of passive avoidance between healthy and control groups there was no significant difference but there is a significantly decreased between the control group and the group receiving methamphetamine. Increase learning and short-term memory and reduced long term memory and passive avoidance learning mechanism is probably due to the involvement of the hippocampus in learning and memory consolidation and short term memory convert to long-term memory could potential mechanism of methamphetamine-induced damage to hippocampal neurons, particularly CA1 neurons. Meanwhile, short-term memory-enhancing effects of methamphetamine can result in Increase cortisol is also a short-term strengthens to the memory but in long term it will damage and weaken the memory.
Methamphetamine, Passive Avoidance Learning, Male Rat
To cite this article
Milad Rezazadeh, Mehdi Ahmadifar, Meysam Ahmadi Manesh, The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats, Advances in Applied Physiology. Vol. 3, No. 1, 2018, pp. 1-7. doi: 10.11648/j.aap.20180301.11
Copyright © 2018 Authors retain the copyright of this article.
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